Oxidative Stress, Inflammation, and Health,9780824727338

Oxidative Stress, Inflammation, and Health

by ;
ISBN13: 9780824727338
ISBN10: 0824727339
Format: Hardcover
Pub. Date: 2005-05-24
Publisher(s): CRC Press
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Summary

Specifically focusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference provides a comprehensive overview of cutting-edge research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors-analyzing the implications of oxidative stress and inflammatory damage in the pathogenesis of human disorders such as cancer, neurodegenerative disease, and diabetes.

Table of Contents

Series Introduction iii
Preface ix
Contributors xi
1. Oxidants and Antioxidants: Mechanism of Action and Regulation of Gene Expression by Bioflavonoids
1(20)
Lester Packer
Abstract
1(1)
Introduction to Free Radicals and Antioxidants
2(2)
Mechanisms of Antioxidant Defense by Flavonoids
4(3)
Oxidative Stress and the Antioxidant Network
7(2)
Redox Regulation of Gene Expression
9(3)
Neuroactive Responses In Vivo to Ginkgo Biloba EGb 761
12(9)
2. Transcriptional Regulation of Cellular Antioxidant Defense Mechanisms
21(20)
Young-Joon Surh
Toxicological vs. Physiological Functions of ROS
22(2)
Adaptive Response to Oxidative Injuries
24(1)
Cellular Antioxidant Defenses
25(2)
Transcriptional Regulation of Cellular Antioxidant and Detoxifying Enzymes
27(6)
ARE as a Critical Component of Nrf2-Mediated Antioxidant Defense
33(1)
Summary
33(8)
3. Redox Regulation of Inflammatory Tissue Damage by Thioredoxin
41(20)
Shugo Ueda, Hajime Nakamura, Takayuki Nakamura, and Junji Yodoi
Abstract
41(1)
Introduction-Redox Control by Thioredoxin System
42(2)
TRX Family
44(1)
TRX System and Modulation of
Signal Transduction
45(2)
Extracellular TRX
47(1)
TRX-Knockout Mouse
48(1)
TRX-Transgenic Mouse
49(1)
Therapeutic Approach Using Recombinant Human TRX-Translational Research
50(1)
Concluding Remarks
51(10)
4. Regulation of NF-kB-Driven Inflammatory Genes by Phytoestrogens
61(46)
Wim Vanden Berghe, Nathalie Dijsselbloem, An De Naeyer, Linda Vermeulen, and Guy Haegeman
Introduction
61(2)
(Phyto)Estrogens
63(5)
NF-kB
68(5)
Induction Mechanisms of NF-kB-Driven Gene Induction
73(4)
Negative Modulation of NF-kB-Driven Gene Induction by Phytoestrogens
77(4)
Conclusion
81(26)
5. Nuclear Factor-kB as Target for Chemoprevention
107(20)
Bharat B. Aggarwal
Abbreviations
107(1)
Abstract
107(1)
Carcinogenesis/Tumorigenesis
108(1)
Cigarette Smoke and Cancer
109(2)
Effect of Cigarette Smoke on Pulmonary Inflammation
111(1)
Oxidative Damage by Cigarette Smoke
112(1)
Composition of Cigarette Smoke
112(1)
What is NF-kB?
113(1)
Relevance of NF-kB to Cigarette Smoking
114(1)
Why NF-kB Is Important for Cancer?
114(3)
Chemopreventive Agents Inhibit NF-kB Activation
117(1)
Conclusion
118(9)
6. Heme Oxygenase-1: An Emerging Major Cellular Defense Against Cigarette Smoke-Induced Oxidative Stress and Cytotoxicity
127(18)
Thomas Müller
Abstract
127(1)
Introduction
128(2)
HO-1 Is the Most Strongly Induced Antioxidant Gene in CS-Exposed Cells, In Vitro and In Vivo
130(2)
CS-Exposed Fibroblasts with Impaired HO-1 Inducibility Exhibit Increased Cytotoxicity
132(1)
Swiss 3T3 Cells with Compromised HO-1 Inducibility Undergo Apoptosis When Exposed to CS
133(2)
The CS-Dependent Apoptotic Signal Is Transduced by JNK and p38 MAPK Pathways
135(1)
Absence of HO-1 Expression Is Associated with Apoptosis Induction in CS-Exposed U937 Cells
136(2)
Concluding Remarks
138(7)
7. Biphasic Induction of HO-1 in Macrophages Treated with Lipopolysaccharide: Role of HO-1 Induction in Cell Survival from Oxidative Stress
145(50)
Klaokwan Srisook and Young-Nam Cha
Introduction
145(5)
Protective Effect of NO Against Cytotoxicity of ROS Only in the Presence of GSH
150(2)
Oxidative Stress and Inductions of iNOS and HO-1
152(3)
Heme Oxygenase
155(4)
Co-operative Interaction Between iNOS and HO-1
159(7)
LPS-Derived Depletion of GSH and Sequential Induction of iNOS and HO-1
166(13)
Conclusion
179(16)
8. The Role of Gα12 Proteins in the PKC and JNK-Dependent Induction of NOS by Thrombin
195(14)
Sang Geon Kim, So Yeon Choi, Min Kyung Cho, Keon Wook Kang, and Chang Ho Lee
Abbreviations
195(1)
Abstract
196(2)
Induction of iNOS by Thrombin
198(1)
Activation of NF-kB Transcription Factor
198(2)
NOS Induction and NF-kB Activation by Ga12/13
200(1)
PKC-Mediated NF-kB Activation Downstream of Gα12/13
200(2)
The Role of MAP Kinases in iNOS Induction
202(1)
Coupling of Ga12/13 to JNK
202(1)
JNK-Dependent Degradation of Phosphorylated I-kBα
203(1)
Conclusions
204(5)
9. Actions of 8-Hydroxyguanine in DNA
209(12)
Jin Won Hyun and Myung Hee Chung
Introduction
209(1)
8-Hydroxyguanine (8-Oxoguanine; oh8Gua) and Its Repair Enzymes
210(1)
Model for 8-Hydroxyguanine Studies
211(3)
8-Hydroxyguanine in DNA and Apoptosis
214(1)
Radiation, OGG1, and 8-Hydroxyguanine
215(1)
Conclusion
216(5)
10. Role of Oxidative Stress in Hypercholesterolemia-Induced Inflammation 221(24)
Karen Y. Stokes, Anitaben Tailor, and D. Neil Granger
Introduction
221(1)
Oxidative Stress-Generating Systems in Hypercholesterolemia
222(4)
Oxidative Stress and Inflammatory Responses During Hypercholesterolemia
226(7)
Linkage Between Microvascular and Macrovascular Responses to Hypercholesterolemia
233(1)
Antioxidant Strategies in Hypercholesterolemia
234(2)
Conclusions
236(9)
11. Oxidative Stress in Rheumatoid Arthritis 245(26)
Takashi Okamoto
Introduction
245(2)
Pathophysiology of RA
247(1)
Involvement of NF-kB in RA as a Primary Pathogenic Determinant
248(2)
Oxidative Stress in RA
250(1)
Oxido-Reduction of Proteins as a Signal: Redox Regulation
251(1)
Signaling Cascade for NF-kB Activation
251(6)
Roles of Thioredoxin in RA Pathophysiology
257(4)
Conclusion
261(10)
12. Roles of Carbon Monoxide and Nitric Oxide in Liver Damage 271(20)
Hun-Taeg Chung, Hyun-Ock Pae, Byung-Min Choi, and Soo-Cheon Chae
Introduction
271(1)
Roles of NO in Liver Damage
272(4)
Roles of CO in Liver Damage
276(4)
Interaction Between CO and NO in the Liver
280(2)
Conclusion
282(9)
13. Role of Oxidative Stress and Inflammatory Response in Smokers and Chronic Obstructive Pulmonary Disease 291(78)
Irfan Rahman
Abstract
291(1)
Introduction
292(2)
Chronic Obstructive Pulmonary Disease
294(1)
Cell-Derived ROS
294(4)
Inhaled Oxidants and Cigarette Smoke
298(2)
Alterations in the Alveolar Space
300(1)
Alterations in Blood
301(1)
Reactive Oxygen and Reactive Nitrogen Species as Surrogate Markers in Plasma and Exhaled Breath Condensate
302(7)
Depletion of Antioxidants
309(3)
Depletion of Glutathione
312(1)
Other Auxiliary Antioxidants
313(1)
Consequences of Oxidant/Antioxidant Imbalance
314(1)
Mucus Hypersecretion
315(1)
Remodeling of Extracellular Matrix
316(1)
Apoptosis
317(1)
Muscle Dysfunction
317(1)
Oxidative Stress and the Development of Airway Obstruction
318(1)
Inflammation and Gene Expression
319(6)
Antioxidant Protective Genes
325(3)
Chromatin Remodeling (Histone Acetylation and Deacetylation) and Glucocorticoid Inefficacy
328(5)
Inflammation and Adenoviral E1A
333(1)
Oxidative Stress and Susceptibility to COPD
334(1)
Antioxidant Therapeutic Interventions
335(1)
Thiol Compounds
336(4)
Conclusion
340(29)
14. Association of Chronic Inflammation with Carcinogenesis: Implications of Anti-inflammatory Strategies for Cancer Prevention 369(20)
Marie Yeo, Sang Uk Han, Ki Taik Nam, Dae Young Kim, Sung Won Cho, and Ki-Baik Hahm
Abstract
369(1)
Introduction
370(1)
Association of Chronic Inflammation and Cancer in Gastroenterology
371(1)
Role of Oxidative Stress in GI Carcinogenesis
372(2)
Procancer Microenvironment Formation by Chronic, Persistent Inflammation
374(6)
Anti-Inflammatory Treatment as Cancer Prevention Strategy
380(9)
15. Molecular Inflammation as an Underlying Mechanism of Aging: The Anti-inflammatory Action of Calorie Restriction 389(34)
Hae Young Chung, Kyung Jin Jung, and Byung Pal Yu
Introduction
389(3)
Biological Generation Sites of Reactive Species
392(1)
Inflammation Caused by Oxidative Stress
393(4)
Status of NF-kB in Inflammation and Aging
397(2)
Regulation of NF-kB Activation by IKK/NIK and MAPK
399(5)
Bases for Molecular Inflammation in Aging
404(1)
Supporting Evidence for the Molecular Inflammation Hypothesis
405(5)
Conclusion
410(13)
16. Oxidative Stress in Mitochondria: The Involvement in Neurodegenerative Diseases 423(22)
Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Nagai, Yoji Kato, and Masashi Tanaka Abstract
424(21)
Oxidative Stress and Modified Protein as the Marker
425(4)
Mitochondrial Complex I Subunits Are Nitrated by ONOO-
429(5)
Proteasome: Its Role in Accumulation of Oxidized Proteins
434(1)
Mitochondrial Dysfunction Inhibits the Proteasome System by Oxidative Modification
435(3)
Conclusion
438(7)
17. Implications of Inflammatory Stress in Alzheimer's Disease 445(26)
Jung-Hee Jang and Young-Joon Surh
Introduction
445(1)
Elevated Inflammatory Responses in AD
446(3)
Anti-inflammatory Therapy for AD
449(1)
Roles of COX-2 and Nitrosative Stress in Neuronal Cell Death
450(4)
Cross-Talk Between iNOS and COX Pathways in Inflammation
454(2)
Transcription Factors and Upstream Intracellular Signaling Molecules in Αβ-Induced Inflammation
456(5)
Conclusion and Future Directions
461(10)
18. Biomarkers for Evaluating Antioxidant Effects 471(30)
Robin van den Berg, Henk van den Berg, Guido R.M.M. Haenen, and Aalt Bast
Free Radicals and Antioxidants: Need or Threat?
471(4)
How to Assess/Quantify Health Benefits From Antioxidants in Humans
475(6)
Methodologies of Markers for Evaluating Antioxidant Protection and Oxidative Damage
481(6)
Methods of Assessing Oxidative Damage
487(14)
19. Antioxidant and Neuroprotective Potentials 501(24)
Muhammad Soobrattee, Theeshan Bahorun, and Okezie I. Aruoma
RNS/ROS and Oxidative Stress
501(1)
Neurodegenerative Disorders
502(1)
Alzheimer's Disease
503(3)
Antioxidants as Prophylactic Agents in the Management of AD
506(19)
20. Resveratrol-A Unique Polyphenolic Antioxidant Present in Grape Skins and Red Wine-Is a Preventive Medicine Against a Variety of Degenerative Diseases 525(24)
Dipak K. Das and Nilanjana Maulik
Abstract
525(1)
Introduction
526(2)
Resveratrol
528(3)
Preconditioning with Resveratrol
531(8)
Summary and Conclusion
539(10)
21. Molecular Mechanisms of Prevention Against Allergic Rhinitis by Aller-7, A Novel Polyherbal Formulation 549(38)
Debasis Bagchi, Amit Agarwal, Vinod S. Saxena, and Manashi Bagchi
Abstract
549(1)
Introduction
550(5)
Safety
555(6)
Pharmacological Activity Studies
561(16)
Human Clinical Studies
577(5)
Conclusion
582(5)
22. Antioxidant Character of Selenium and Its Survival Signals by Activation of PI3-K/Akt Pathways 587(22)
Sang-Oh Yoon, Jong-Min Park, and An-Sik Chung
Introduction
587(1)
Selenium Deficiency and Glutathione Peroxidase Activity
588(2)
Selenium Increases Cell Proliferation and Blocks Apoptosis Induced by H2O2
590(1)
Selenite Inhibits H2O2-Induced Apoptosis via the Inhibition of ASK1 Activity and Activation of PI3-K-Dependent Akt Activity
591(4)
Selenium Increases Glucose Uptake, ATP Generation, Mitochondrial Membrane Potential, and BCL-2 Expression but Decreases Caspase Activity
595(5)
Concluding Remarks
600(9)
23. Neuroprotection by Rasagiline and Related Propargylamines Is Mediated by Suppression of Mitochondrial Death Signal and Induction of Antiapoptotic Genes 609(22)
Wakako Maruyama, Yukihiro Akao, Makoto Naoi, and Atsumi Nitta
Abstract
610(1)
Neuroprotection by Propargylamines: Intracellular Mechanism
611(2)
Induction of Neuroprotective Protein
613(9)
Discussion
622(9)
Index 631

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